Ontology highlight
ABSTRACT:
SUBMITTER: Song J
PROVIDER: S-EPMC1857715 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Song Jeongmin J Duncan Matthew J MJ Li Guojie G Chan Cheryl C Grady Richard R Stapleton Ann A Abraham Soman N SN
PLoS pathogens 20070401 4
The vigorous cytokine response of immune cells to Gram-negative bacteria is primarily mediated by a recognition molecule, Toll-like receptor 4 (TLR4), which recognizes lipopolysaccharide (LPS) and initiates a series of intracellular NF-kappaB-associated signaling events. Recently, bladder epithelial cells (BECs) were reported to express TLR4 and to evoke a vigorous cytokine response upon exposure to LPS. We examined intracellular signaling events in human BECs leading to the production of IL-6, ...[more]