Ontology highlight
ABSTRACT:
SUBMITTER: Song J
PROVIDER: S-EPMC2736405 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Song Jeongmin J Bishop Brian L BL Li Guojie G Grady Richard R Stapleton Ann A Abraham Soman N SN
Proceedings of the National Academy of Sciences of the United States of America 20090817 35
Uropathogenic Escherichia coli invade bladder epithelial cells (BECs) by direct entry into specialized cAMP regulated exocytic compartments. Remarkably, a significant number of these intracellular bacteria are subsequently expelled in a nonlytic and piecemeal fashion by infected BECs. Here, we report that expulsion of intracellular E. coli by infected BECs is initiated by the pattern recognition receptor, Toll-like receptor (TLR)4, after activation by LPS. Also, we reveal that caveolin-1, Rab27b ...[more]