Ontology highlight
ABSTRACT:
SUBMITTER: Krendel M
PROVIDER: S-EPMC1861834 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Krendel Mira M Osterweil Emily K EK Mooseker Mark S MS
FEBS letters 20070118 4
Myosin 1E is one of two "long-tailed" human Class I myosins that contain an SH3 domain within the tail region. SH3 domains of yeast and amoeboid myosins I interact with activators of the Arp2/3 complex, an important regulator of actin polymerization. No binding partners for the SH3 domains of myosins I have been identified in higher eukaryotes. In the current study, we show that two proteins with prominent functions in endocytosis, synaptojanin-1 and dynamin, bind to the SH3 domain of human Myo1 ...[more]