Ontology highlight
ABSTRACT:
SUBMITTER: Sebastian S
PROVIDER: S-EPMC1865767 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Sebastian Shite S Dillon Simon T ST Lynch Jillian G JG Blalock LeeAnn T LT Balon Emmy E Lee Kristin T KT Comstock Laurie E LE Conlan J Wayne JW Rubin Eric J EJ Tzianabos Arthur O AO Kasper Dennis L DL
Infection and immunity 20070212 5
Francisella tularensis, the causative agent of tularemia, has been designated a CDC category A select agent because of its low infective dose (<10 CFU), its ready transmission by aerosol, and its ability to produce severe morbidity and high mortality. The identification and characterization of this organism's virulence determinants will facilitate the development of a safe and effective vaccine. We report that inactivation of the wbtA-encoded dehydratase of the O-antigen polysaccharide (O-PS) lo ...[more]