Ontology highlight
ABSTRACT:
SUBMITTER: Botten J
PROVIDER: S-EPMC1865925 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Botten Jason J Whitton J Lindsay JL Barrowman Polly P Sidney John J Whitmire Jason K JK Alexander Jeff J Ting Joey P C JP Bui Huynh-Hoa HH Sette Alessandro A Buchmeier Michael J MJ
Journal of virology 20061213 5
The consequences of human lymphocytic choriomeningitis virus (LCMV) infection can be severe, including aseptic meningitis in immunocompetent individuals, hydrocephalus or chorioretinitis in fetal infection, or a highly lethal outcome in immunosuppressed individuals. In murine models of LCMV infection, CD8(+) T cells play a primary role in providing protective immunity, and there is evidence that cellular immunity may also be important in related arenavirus infections in humans. For this reason, ...[more]