Ontology highlight
ABSTRACT:
SUBMITTER: Gawlinski P
PROVIDER: S-EPMC1866202 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Gawliński Pawel P Nikolay Rainer R Goursot Catherine C Lawo Steffen S Chaurasia Bhagirath B Herz Hans-Martin HM Kussler-Schneider Yvonne Y Ruppert Thomas T Mayer Matthias M Grosshans Jörg J
EMBO reports 20070413 5
The hydrophobic patch of cyclins interacts with cyclin-dependent kinase (Cdk) substrates and p27-type Cdk inhibitors. Although this interaction is assumed to contribute to the specificity of different Cdk-Cyclin complexes, its role in specific steps of the cell cycle has not been demonstrated. Here, we show that in Drosophila the mitotic inhibitor Frühstart (Frs) binds specifically and with high affinity to the hydrophobic patch of cyclins. In contrast to p27-type Cdk inhibitors, Frs does not fo ...[more]