The roles of Drosophila cyclins A and B in mitotic control.
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ABSTRACT:
SUBMITTER: Lehner CF
PROVIDER: S-EPMC2753431 | biostudies-literature | 1990 May
REPOSITORIES: biostudies-literature
Publications
The roles of Drosophila cyclins A and B in mitotic control.
Lehner C F CF O'Farrell P H PH
Cell 19900501 3
We have cloned, sequenced, and characterized the expression of a Drosophila cyclin B gene. The independent evolutionary conservation of A- and B-type cyclins implies that they have distinct roles. Indeed, in mutant embryos deficient in cyclin A, cells that accumulate only cyclin B do not enter mitosis. Thus, in vivo, cyclin B is not sufficient for mitosis. Furthermore, we find that the two cyclins are coexpressed in all proliferating cells throughout development. Though lacking a formal demonstr ...[more]
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