Identification of tag single-nucleotide polymorphisms in regions with varying linkage disequilibrium.
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ABSTRACT:
SUBMITTER: Duggal P
PROVIDER: S-EPMC1866708 | biostudies-literature | 2005
REPOSITORIES: biostudies-literature
Publications
Identification of tag single-nucleotide polymorphisms in regions with varying linkage disequilibrium.
Duggal Priya P Gillanders Elizabeth M EM Mathias Rasika A RA Ibay Grace P GP Klein Alison P AP Baffoe-Bonnie Agnes B AB Ou Liang L Dusenberry Ian P IP Tsai Ya-Yu YY Chines Peter S PS Doan Betty Q BQ Bailey-Wilson Joan E JE
BMC genetics 20051230
We compared seven different tagging single-nucleotide polymorphism (SNP) programs in 10 regions with varied amounts of linkage disequilibrium (LD) and physical distance. We used the Collaborative Studies on the Genetics of Alcoholism dataset, part of the Genetic Analysis Workshop 14. We show that in regions with moderate to strong LD these programs are relatively consistent, despite different parameters and methods. In addition, we compared the selected SNPs in a multipoint linkage analysis for ...[more]
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