Impaired expression of NER gene network in sporadic solid tumors.
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ABSTRACT:
SUBMITTER: Castro MA
PROVIDER: S-EPMC1874609 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Publications
Impaired expression of NER gene network in sporadic solid tumors.
Castro Mauro A A MA Mombach José C M JC de Almeida Rita M C RM Moreira José C F JC
Nucleic acids research 20070301 6
Nucleotide repair genes are not generally altered in sporadic solid tumors. However, point mutations are found scattered throughout the genome of cancer cells indicating that the repair pathways are dysfunctional. To address this point, in this work we focus on the expression pathways rather than in the DNA structure of repair genes related to either genome stability or essential metabolic functions. We present here a novel statistical analysis comparing ten gene expression pathways in human nor ...[more]
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