A nonsense mutation in the FMO3 gene underlies fishy off-flavor in cow's milk.
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ABSTRACT:
SUBMITTER: Lunden A
PROVIDER: S-EPMC187563 | biostudies-literature | 2002 Dec
REPOSITORIES: biostudies-literature
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A nonsense mutation in the FMO3 gene underlies fishy off-flavor in cow's milk.
Lundén Anne A Marklund Stefan S Gustafsson Victoria V Andersson Leif L
Genome research 20021201 12
Fish-odor syndrome or Trimethylaminuria (OMIM #602079) in humans is an inborn error of metabolism associated with a characteristic fishy body odor due to elevated levels of trimethylamine (TMA) in body fluids. It is caused by loss-of-function mutations in FMO3 encoding flavin-containing mono-oxygenase 3. A fishy off-flavor is occasionally observed in cow's milk and it has been established recently that this phenotype is due to elevated TMA levels. Here, we report that fishy off-flavor in cow's m ...[more]
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