Ontology highlight
ABSTRACT:
SUBMITTER: Dai P
PROVIDER: S-EPMC1877122 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Dai Ping P Nakagami Takuo T Tanaka Hideo H Hitomi Toshiaki T Takamatsu Tetsuro T
Molecular biology of the cell 20070411 6
Transforming growth factor-beta (TGF-beta) superfamily members play an important role in growth, differentiation, adhesion, apoptosis, and development in many species from insects and worms to vertebrates. Recently, TGF-beta signaling has been demonstrated to be negatively regulated by microtubules (MTs), which anchor endogenous Smad2/3 to cytosol and also directly interact with connexin43 (Cx43), and the activity of TGF-beta is mediated by Cx43. However, the mechanism underlying the intracellul ...[more]