Ontology highlight
ABSTRACT:
SUBMITTER: Wallace IM
PROVIDER: S-EPMC1878507 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Wallace Iain M IM Higgins Desmond G DG
BMC bioinformatics 20070423
<h4>Background</h4>Proteins that evolve from a common ancestor can change functionality over time, and it is important to be able identify residues that cause this change. In this paper we show how a supervised multivariate statistical method, Between Group Analysis (BGA), can be used to identify these residues from families of proteins with different substrate specifities using multiple sequence alignments.<h4>Results</h4>We demonstrate the usefulness of this method on three different test case ...[more]