Ontology highlight
ABSTRACT:
SUBMITTER: Geisler SB
PROVIDER: S-EPMC1885211 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Geisler Sarah B SB Robinson Dustin D Hauringa Maria M Raeker Maide O MO Borisov Andrei B AB Westfall Margaret V MV Russell Mark W MW
Genomics 20070206 4
Cytoskeletal adaptor proteins serve vital functions in linking the internal cytoskeleton of cells to the cell membrane, particularly at sites of cell-cell and cell-matrix interactions. The importance of these adaptors to the structural integrity of the cell is evident from the number of clinical disease states attributable to defects in these networks. In the heart, defects in the cytoskeletal support system that surrounds and supports the myofibril result in dilated cardiomyopathy and congestiv ...[more]