Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Heart
SUBMITTER: Majid Ghassemian
LAB HEAD: majid ghassemian
PROVIDER: PXD013008 | Pride | 2019-05-20
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
SL_Soleus_TMT5_01.mgf | Mgf | |||
SL_Soleus_TMT5_01.pride.mgf.gz | Mgf | |||
SL_Soleus_TMT5_01.raw | Raw | |||
SL_Soleus_TMT5_010.mgf | Mgf | |||
SL_Soleus_TMT5_010.pride.mgf.gz | Mgf |
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Blondelle Jordan J Marrocco Valeria V Clark Madison M Desmond Patrick P Myers Stephanie S Nguyen Jim J Wright Matthew M Bremner Shannon S Pierantozzi Enrico E Ward Samuel S Estève Eric E Sorrentino Vincenzo V Ghassemian Majid M Lange Stephan S
Communications biology 20190509
Biological roles of obscurin and its close homolog Obsl1 (obscurin-like 1) have been enigmatic. While obscurin is highly expressed in striated muscles, Obsl1 is found ubiquitously. Accordingly, obscurin mutations have been linked to myopathies, whereas mutations in Obsl1 result in 3M-growth syndrome. To further study unique and redundant functions of these closely related proteins, we generated and characterized Obsl1 knockouts. Global Obsl1 knockouts are embryonically lethal. In contrast, skele ...[more]