Proteomics

Dataset Information

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Obscurin and Obsl1 functions for “Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism.”


ABSTRACT: “Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism.”

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart

SUBMITTER: Majid Ghassemian  

LAB HEAD: majid ghassemian

PROVIDER: PXD013008 | Pride | 2019-05-20

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
SL_Soleus_TMT5_01.mgf Mgf
SL_Soleus_TMT5_01.pride.mgf.gz Mgf
SL_Soleus_TMT5_01.raw Raw
SL_Soleus_TMT5_010.mgf Mgf
SL_Soleus_TMT5_010.pride.mgf.gz Mgf
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Publications

Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism.

Blondelle Jordan J   Marrocco Valeria V   Clark Madison M   Desmond Patrick P   Myers Stephanie S   Nguyen Jim J   Wright Matthew M   Bremner Shannon S   Pierantozzi Enrico E   Ward Samuel S   Estève Eric E   Sorrentino Vincenzo V   Ghassemian Majid M   Lange Stephan S  

Communications biology 20190509


Biological roles of obscurin and its close homolog Obsl1 (obscurin-like 1) have been enigmatic. While obscurin is highly expressed in striated muscles, Obsl1 is found ubiquitously. Accordingly, obscurin mutations have been linked to myopathies, whereas mutations in Obsl1 result in 3M-growth syndrome. To further study unique and redundant functions of these closely related proteins, we generated and characterized Obsl1 knockouts. Global Obsl1 knockouts are embryonically lethal. In contrast, skele  ...[more]

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