Unknown

Dataset Information

0

An easy synthesis of 5-functionally substituted ethyl 4-amino-1-aryl- pyrazolo-3-carboxylates: interesting precursors to sildenafil analogues.


ABSTRACT: 3-Oxo-2-arylhydrazononitriles 1a-c react readily with chloroacetonitrile, ethyl chloroacetate, and with phenacyl chloride to give 4-aminopyrazoles 4a-e. The pyrazolo[4,3-d]pyrimidine derivatives 7 and 10 are synthesized via reaction of the aminopyrazole 4b with phenylisothiocyanate and DMFDMA/NH4OAc respectively.

SUBMITTER: Ghozlan SA 

PROVIDER: S-EPMC1885264 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

An easy synthesis of 5-functionally substituted ethyl 4-amino-1-aryl- pyrazolo-3-carboxylates: interesting precursors to sildenafil analogues.

Ghozlan Said A S SA   Badahdah Khadija O KO   Abdelhamid Ismail A IA  

Beilstein journal of organic chemistry 20070501


3-Oxo-2-arylhydrazononitriles 1a-c react readily with chloroacetonitrile, ethyl chloroacetate, and with phenacyl chloride to give 4-aminopyrazoles 4a-e. The pyrazolo[4,3-d]pyrimidine derivatives 7 and 10 are synthesized via reaction of the aminopyrazole 4b with phenylisothiocyanate and DMFDMA/NH4OAc respectively. ...[more]

Similar Datasets

| S-EPMC10052257 | biostudies-literature
| S-EPMC3648271 | biostudies-literature
| S-EPMC4186190 | biostudies-literature
| S-EPMC8386643 | biostudies-literature
| S-EPMC3548967 | biostudies-literature
| S-EPMC2970404 | biostudies-literature
| S-EPMC6837187 | biostudies-literature
| S-EPMC5434896 | biostudies-literature
| S-EPMC2812943 | biostudies-literature
| S-EPMC7248765 | biostudies-literature