Ontology highlight
ABSTRACT:
SUBMITTER: Chen M
PROVIDER: S-EPMC1885484 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Chen Min M Huang Li L Wang Jin J Wang Jin J
Blood 20070116 10
Apoptosis in dendritic cells (DCs) can potentially regulate DC homeostasis and immune responses. We have previously observed that inhibition of the Fas signaling pathway in DCs results in spontaneous T-cell activation and the development of systemic autoimmunity in transgenic mice. However, the role for different apoptosis pathways in DCs in regulating DC homeostasis and immune tolerance remains to be determined. Bim, a BH3-only protein of the Bcl-2 family, was expressed at low levels in DCs and ...[more]