Ontology highlight
ABSTRACT:
SUBMITTER: Durakovic N
PROVIDER: S-EPMC1885486 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Durakovic Nadira N Radojcic Vedran V Skarica Mario M Bezak Karl B KB Powell Jonathan D JD Fuchs Ephraim J EJ Luznik Leo L
Blood 20070116 10
Murine models of bone marrow transplantation were used to study the mechanisms governing the activation of donor lymphocyte infusions (DLIs) manifesting as lymphohematopoietic graft-versus-host (LH-GVH) and graft-versus-leukemia (GVL) reactivities. We demonstrate here that established mixed chimerism influences the potency of DLI-mediated alloreactivity only in the MHC-mismatched but not MHC-matched setting. In the MHC-matched setting, high levels (>or= 40%) of residual host chimerism correlated ...[more]