Ontology highlight
ABSTRACT:
SUBMITTER: Sanyal M
PROVIDER: S-EPMC1885499 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Sanyal Mrinmoy M Tung James W JW Karsunky Holger H Zeng Hong H Selleri Licia L Weissman Irving L IL Herzenberg Leonore A LA Cleary Michael L ML
Blood 20070123 10
Pbx1, a homeodomain transcription factor that was originally identified as the product of a proto-oncogene in acute pre-B-cell leukemia, is a global regulator of embryonic development. However, embryonic lethality in its absence has prevented an assessment of its role in B-cell development. Here, using Rag1-deficient blastocyst complementation assays, we demonstrate that Pbx1 null embryonic stem (ES) cells fail to generate common lymphoid progenitors (CLPs) resulting in a complete lack of B and ...[more]