Ontology highlight
ABSTRACT:
SUBMITTER: Jakob M
PROVIDER: S-EPMC1885670 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Jakób Michał M Kołodziejczyk Robert R Orłowski Marek M Krzywda Szymon S Kowalska Agnieszka A Dutko-Gwóźdź Joanna J Gwóźdź Tomasz T Kochman Marian M Jaskólski Mariusz M Ozyhar Andrzej A
Nucleic acids research 20070410 8
The heterodimer of the ecdysone receptor (EcR) and ultraspiracle (Usp), members of the nuclear receptors superfamily, is considered as the functional receptor for ecdysteroids initiating molting and metamorphosis in insects. Here we report the 1.95 A structure of the complex formed by the DNA-binding domains (DBDs) the EcR and the Usp, bound to the natural pseudopalindromic response element. Comparison of the structure with that obtained previously, using an idealized response element, shows how ...[more]