Ontology highlight
ABSTRACT:
SUBMITTER: Natan E
PROVIDER: S-EPMC3176915 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Natan Eviatar E Baloglu Cetin C Pagel Kevin K Freund Stefan M V SM Morgner Nina N Robinson Carol V CV Fersht Alan R AR Joerger Andreas C AC
Journal of molecular biology 20110330 3
The tetrameric tumor suppressor p53 plays a pivotal role in the control of the cell cycle and provides a paradigm for an emerging class of oligomeric, multidomain proteins with structured and intrinsically disordered regions. Many of its biophysical and functional properties have been extrapolated from truncated variants, yet the exact structural and functional role of certain segments of the protein is unclear. We found from NMR and X-ray crystallography that the DNA-binding domain (DBD) of hum ...[more]