Effects of environmental enrichment on gene expression in the brain.
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ABSTRACT:
SUBMITTER: Rampon C
PROVIDER: S-EPMC18858 | biostudies-literature | 2000 Nov
REPOSITORIES: biostudies-literature
Publications
Effects of environmental enrichment on gene expression in the brain.
Rampon C C Jiang C H CH Dong H H Tang Y P YP Lockhart D J DJ Schultz P G PG Tsien J Z JZ Hu Y Y
Proceedings of the National Academy of Sciences of the United States of America 20001101 23
An enriched environment is known to promote structural changes in the brain and to enhance learning and memory performance in rodents [Hebb, D. O. (1947) Am. Psychol. 2, 306-307]. To better understand the molecular mechanisms underlying these experience-dependent cognitive changes, we have used high-density oligonucleotide microarrays to analyze gene expression in the brain. Expression of a large number of genes changes in response to enrichment training, many of which can be linked to neuronal ...[more]
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