Ontology highlight
ABSTRACT:
SUBMITTER: Thanos PK
PROVIDER: S-EPMC4991369 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Thanos Panayotis K PK Hamilton John J O'Rourke Joseph R JR Napoli Anthony A Febo Marcelo M Volkow Nora D ND Blum Kenneth K Gold Mark M
Oncotarget 20160401 15
Aging produces cellular, molecular, and behavioral changes affecting many areas of the brain. The dopamine (DA) system is known to be vulnerable to the effects of aging, which regulate behavioral functions such as locomotor activity, body weight, and reward and cognition. In particular, age-related DA D2 receptor (D2R) changes have been of particular interest given its relationship with addiction and other rewarding behavioral properties. Male and female wild-type (Drd2 +/+), heterozygous (Drd2 ...[more]