Ontology highlight
ABSTRACT:
SUBMITTER: Carrasco DR
PROVIDER: S-EPMC1885943 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Cancer cell 20070401 4
Multiple myeloma (MM) evolves from a highly prevalent premalignant condition termed MGUS. The factors underlying the malignant transformation of MGUS are unknown. We report a MGUS/MM phenotype in transgenic mice with Emu-directed expression of the XBP-1 spliced isoform (XBP-1s), a factor governing unfolded protein/ER stress response and plasma-cell development. Emu-XBP-1s elicited elevated serum Ig and skin alterations. With age, Emu-xbp-1s transgenics develop features diagnostic of human MM, in ...[more]