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Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling.


ABSTRACT: In neurons, intracellular calcium signals have crucial roles in activating neurotransmitter release and in triggering alterations in neuronal function. Calmodulin has been widely studied as a Ca(2+) sensor that has several defined roles in neuronal Ca(2+) signalling, but members of the neuronal calcium sensor protein family have also begun to emerge as key components in a number of regulatory pathways and have increased the diversity of neuronal Ca(2+) signalling pathways. The differing properties of these proteins allow them to have discrete, non-redundant functions.

SUBMITTER: Burgoyne RD 

PROVIDER: S-EPMC1887812 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature

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Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling.

Burgoyne Robert D RD  

Nature reviews. Neuroscience 20070301 3


In neurons, intracellular calcium signals have crucial roles in activating neurotransmitter release and in triggering alterations in neuronal function. Calmodulin has been widely studied as a Ca(2+) sensor that has several defined roles in neuronal Ca(2+) signalling, but members of the neuronal calcium sensor protein family have also begun to emerge as key components in a number of regulatory pathways and have increased the diversity of neuronal Ca(2+) signalling pathways. The differing properti  ...[more]

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