Ontology highlight
ABSTRACT:
SUBMITTER: Chi SW
PROVIDER: S-EPMC1890477 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Chi Seung-Wook SW Maeng Cheol-Young CY Kim Seung Jun SJ Oh Mee Sook MS Ryu Chun Jeih CJ Kim Sang Jick SJ Han Kyou-Hoon KH Hong Hyo Jeong HJ Ryu Seong Eon SE
Proceedings of the National Academy of Sciences of the United States of America 20070517 22
The humanized monoclonal antibody HzKR127 recognizes the preS1 domain of the human hepatitis B virus surface proteins with a broadly neutralizing activity in vivo. We present the crystal structures of HzKR127 Fab and its complex with a major epitope peptide. In the complex structure, the bound peptide forms a type IV beta-turn followed by 3(10) helical turn, the looped-out conformation of which provides a structural basis for broad neutralization. Upon peptide binding, the antibody undergoes a d ...[more]