Ontology highlight
ABSTRACT:
SUBMITTER: Liu G
PROVIDER: S-EPMC7141872 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Liu Ge G Zeng Haoyang H Mueller Jonas J Carter Brandon B Wang Ziheng Z Schilz Jonas J Horny Geraldine G Birnbaum Michael E ME Ewert Stefan S Gifford David K DK
Bioinformatics (Oxford, England) 20200401 7
<h4>Motivation</h4>The precise targeting of antibodies and other protein therapeutics is required for their proper function and the elimination of deleterious off-target effects. Often the molecular structure of a therapeutic target is unknown and randomized methods are used to design antibodies without a model that relates antibody sequence to desired properties.<h4>Results</h4>Here, we present Ens-Grad, a machine learning method that can design complementarity determining regions of human Immu ...[more]