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Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1.

ABSTRACT: beta-Lactam resistance in Haemophilus parasuis is an emerging phenomenon that has not yet been characterized from a molecular perspective. Clinical high-level beta-lactam-resistant isolates from Spain bore a novel plasmid, pB1000, expressing a functionally active ROB-1 beta-lactamase. Pulsed-field gel electrophoresis was applied for the first time to H. parasuis and showed that beta-lactam resistance is due to clonal spread of a resistant strain, BB1018, bearing pB1000.

SUBMITTER: San Millan A 

PROVIDER: S-EPMC1891367 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature

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Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1.

San Millan Alvaro A   Escudero Jose Antonio JA   Catalan Ana A   Nieto Silvia S   Farelo Fidel F   Gibert Magdalena M   Moreno Miguel Angel MA   Dominguez Lucas L   Gonzalez-Zorn Bruno B  

Antimicrobial agents and chemotherapy 20070416 6

beta-Lactam resistance in Haemophilus parasuis is an emerging phenomenon that has not yet been characterized from a molecular perspective. Clinical high-level beta-lactam-resistant isolates from Spain bore a novel plasmid, pB1000, expressing a functionally active ROB-1 beta-lactamase. Pulsed-field gel electrophoresis was applied for the first time to H. parasuis and showed that beta-lactam resistance is due to clonal spread of a resistant strain, BB1018, bearing pB1000. ...[more]

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