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Broad-spectrum antiviral activity of small interfering RNA targeting the conserved RNA termini of Lassa virus.

ABSTRACT: Small interfering RNAs targeting the conserved RNA termini upstream of NP and L gene were found to reduce reporter gene expression from Lassa virus replicon and Lassa virus mRNA expression construct and to inhibit replication of different Lassa virus strains, lymphocytic choriomeningitis virus, and Mopeia virus in cell culture.

SUBMITTER: Muller S 

PROVIDER: S-EPMC1891391 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature

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Broad-spectrum antiviral activity of small interfering RNA targeting the conserved RNA termini of Lassa virus.

Müller Stefanie S   Günther Stephan S  

Antimicrobial agents and chemotherapy 20070319 6

Small interfering RNAs targeting the conserved RNA termini upstream of NP and L gene were found to reduce reporter gene expression from Lassa virus replicon and Lassa virus mRNA expression construct and to inhibit replication of different Lassa virus strains, lymphocytic choriomeningitis virus, and Mopeia virus in cell culture. ...[more]

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