Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases.
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ABSTRACT:
SUBMITTER: Xie J
PROVIDER: S-EPMC1894594 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Publications
Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases.
Xie Jing J Bessling Seneca L SL Cooper Timothy K TK Dietz Harry C HC McCallion Andrew S AS Fisher Shannon S
Genetics 20070504 2
RecQ DNA helicases resolve Rad-51-mediated recombination and suppress aberrant homologous recombination. RecQ gene loss is associated with cancer susceptibility and increased mitotic recombination. We have developed an in vivo assay based on a zebrafish pigment mutant for suppression of RecQ activity, and demonstrate that zebrafish RecQ genes have conserved function in suppressing mitotic recombination. ...[more]
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