Ontology highlight
ABSTRACT:
SUBMITTER: Yamanaka K
PROVIDER: S-EPMC1895734 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Yamanaka Kei-ichi K Clark Rachael R Rich Benjamin B Dowgiert Rebecca R Hirahara Kazuki K Hurwitz Daniel D Shibata Michio M Mirchandani Nina N Jones David A DA Goddard Deborah S DS Eapen Sara S Mizutani Hitoshi H Kupper Thomas S TS
Blood 20051201 6
Cutaneous T-cell lymphomas (CTCLs) are malignancies of T cells that have a special affinity for the skin. We have previously reported that much of the T-cell receptor repertoire is altered in CTCL, and both malignant and nonmalignant clones are numerically expanded, presumably in response to T-cell trophic cytokines. We therefore examined levels of the T-cell trophic cytokines IL-2, IL-4, IL-7, IL-12, IL-13, and IL-15 in plasma in 93 CTCL patients and healthy controls. Only IL-7 levels were elev ...[more]