Ontology highlight
ABSTRACT:
SUBMITTER: Hodge D
PROVIDER: S-EPMC1895762 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Hodge Denise D Coghill Elise E Keys Janelle J Maguire Tina T Hartmann Belinda B McDowall Alasdair A Weiss Mitchell M Grimmond Sean S Perkins Andrew A
Blood 20051227 8
Erythroid Kruppel-like factor (EKLF, KLF1) plays an important role in definitive erythropoiesis and beta-globin gene regulation but failure to rectify lethal fetal anemia upon correction of globin chain imbalance suggested additional critical EKLF target genes. We employed expression profiling of EKLF-null fetal liver and EKLF-null erythroid cell lines containing an inducible EKLF-estrogen receptor (EKLF-ER) fusion construct to search for such targets. An overlapping list of EKLF-regulated genes ...[more]