Genes invoked in the ovarian transition to menopause.
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ABSTRACT:
SUBMITTER: Zimon A
PROVIDER: S-EPMC1904106 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
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Genes invoked in the ovarian transition to menopause.
Zimon Alison A Erat Anna A Von Wald Tiffany T Bissell Brad B Koulova Anna A Choi Chu H CH Bachvarov Dimcho D Reindollar Richard H RH Usheva Anny A
Nucleic acids research 20060628 11
Menopause and the associated declines in ovarian function are major health issues for women. Despite the widespread health impact of this process, the molecular mechanisms underlying the aging-specific decline in ovarian function are almost completely unknown. To provide the first gene-protein analysis of the ovarian transition to menopause, we have established and contrasted RNA gene expression profiles and protein localization and content patterns in healthy young and perimenopausal mouse ovar ...[more]
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