Ontology highlight
ABSTRACT:
SUBMITTER: Hosen N
PROVIDER: S-EPMC1904175 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Hosen Naoki N Park Christopher Y CY Tatsumi Naoya N Oji Yusuke Y Sugiyama Haruo H Gramatzki Martin M Krensky Alan M AM Weissman Irving L IL
Proceedings of the National Academy of Sciences of the United States of America 20070618 26
Permanent cure of acute myeloid leukemia (AML) by chemotherapy alone remains elusive for most patients because of the inability to effectively eradicate leukemic stem cells (LSCs), the self-renewing component of the leukemia. To develop therapies that effectively target LSC, one potential strategy is to identify cell surface markers that can distinguish LSC from normal hematopoietic stem cells (HSCs). In this study, we employ a signal sequence trap strategy to isolate cell surface molecules expr ...[more]