Ontology highlight
ABSTRACT:
SUBMITTER: Reyes CL
PROVIDER: S-EPMC1904258 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
PloS one 20070711 7
The signal recognition particle (SRP) and its conjugate receptor (SR) mediate cotranslational targeting of a subclass of proteins destined for secretion to the endoplasmic reticulum membrane in eukaryotes or to the plasma membrane in prokaryotes. Conserved active site residues in the GTPase domains of both SRP and SR mediate discrete conformational changes during formation and dissociation of the SRP.SR complex. Here, we describe structures of the prokaryotic SR, FtsY, as an apo protein and in t ...[more]