Ontology highlight
ABSTRACT:
SUBMITTER: Smith JJ
PROVIDER: S-EPMC1911199 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Smith Jennifer J JJ Ramsey Stephen A SA Marelli Marcello M Marzolf Bruz B Hwang Daehee D Saleem Ramsey A RA Rachubinski Richard A RA Aitchison John D JD
Molecular systems biology 20070605
In transcriptional regulatory networks, the coincident binding of a combination of factors to regulate a gene implies the existence of complex mechanisms to control both the gene expression profile and specificity of the response. Unraveling this complexity is a major challenge to biologists. Here, a novel network topology-based clustering approach was applied to condition-specific genome-wide chromatin localization and expression data to characterize a dynamic transcriptional regulatory network ...[more]