Ontology highlight
ABSTRACT:
SUBMITTER: Deas TS
PROVIDER: S-EPMC1913242 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20070507 7
We characterize in vitro resistance to and demonstrate the in vivo efficacy of two antisense phosphorodiamidate morpholino oligomers (PMOs) against West Nile virus (WNV). Both PMOs were conjugated with an Arg-rich peptide. One peptide-conjugated PMO (PPMO) binds to the 5' terminus of the viral genome (5'-end PPMO); the other targets an essential 3' RNA element required for genome cyclization (3' conserved sequence I [3' CSI] PPMO). The 3' CSI PPMO displayed a broad spectrum of antiflavivirus act ...[more]