Interspecies DNA microarray analysis identifies WblA as a pleiotropic down-regulator of antibiotic biosynthesis in Streptomyces.
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ABSTRACT:
SUBMITTER: Kang SH
PROVIDER: S-EPMC1913423 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
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Interspecies DNA microarray analysis identifies WblA as a pleiotropic down-regulator of antibiotic biosynthesis in Streptomyces.
Kang Seung-Hoon SH Huang Jianqiang J Lee Han-Na HN Hur Yoon-Ah YA Cohen Stanley N SN Kim Eung-Soo ES
Journal of bacteriology 20070406 11
Using Streptomyces coelicolor microarrays to discover regulators of gene expression in other Streptomyces species, we identified wblA, a whiB-like gene encoding a putative transcription factor, as a down-regulator of doxorubicin biosynthesis in Streptomyces peucetius. Further analysis revealed that wblA functions pleiotropically to control antibiotic production and morphological differentiation in streptomycetes. Our results reveal a novel biological role for wblA and show the utility of intersp ...[more]
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