Ontology highlight
ABSTRACT:
SUBMITTER: Chenevix-Trench G
PROVIDER: S-EPMC1918224 | biostudies-literature | 1994 Jul
REPOSITORIES: biostudies-literature
Chenevix-Trench G G Kerr J J Friedlander M M Hurst T T Sanderson B B Coglan M M Ward B B Leary J J Khoo S K SK
American journal of human genetics 19940701 1
Rat ovarian surface epithelial cells transformed spontaneously in vitro have been found to have homozygous deletions of the interferon alpha (IFNA) gene. This suggests that inactivation of a tumor-suppressor gene in this region may be crucial for the development of ovarian cancer. We therefore used microsatellite markers and Southern analysis to examine the homologous region in humans--the short arm of chromosome 9--for deletions in sporadic ovarian adenocarcinomas and ovarian tumor cell lines. ...[more]