Ontology highlight
ABSTRACT:
SUBMITTER: Fountain JW
PROVIDER: S-EPMC50378 | biostudies-literature | 1992 Nov
REPOSITORIES: biostudies-literature
Fountain J W JW Karayiorgou M M Ernstoff M S MS Kirkwood J M JM Vlock D R DR Titus-Ernstoff L L Bouchard B B Vijayasaradhi S S Houghton A N AN Lahti J J
Proceedings of the National Academy of Sciences of the United States of America 19921101 21
Genetic studies have implicated the early involvement of a gene on chromosome arm 9p in the development of cutaneous melanoma. We have performed loss-of-heterozygosity studies to confirm these original findings and identify the most frequently rearranged or deleted region of 9p. Eight markers were analyzed, including (from 9pter to proximal 9q) D9S33, the beta-interferon (IFNB1) locus, the alpha-interferon (IFNA) gene cluster, D9S126, D9S3, D9S19, the glycoprotein 4 beta-galactosyltransferase (G ...[more]