Ontology highlight
ABSTRACT:
SUBMITTER: Pettersen HS
PROVIDER: S-EPMC1919486 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Pettersen Henrik Sahlin HS Sundheim Ottar O Gilljam Karin Margaretha KM Slupphaug Geir G Krokan Hans Einar HE Kavli Bodil B
Nucleic acids research 20070530 12
DNA glycosylases UNG and SMUG1 excise uracil from DNA and belong to the same protein superfamily. Vertebrates contain both SMUG1 and UNG, but their distinct roles in base excision repair (BER) of deaminated cytosine (U:G) are still not fully defined. Here we have examined the ability of human SMUG1 and UNG2 (nuclear UNG) to initiate and coordinate repair of U:G mismatches. When expressed in Escherichia coli cells, human UNG2 initiates complete repair of deaminated cytosine, while SMUG1 inhibits ...[more]