Ontology highlight
ABSTRACT:
SUBMITTER: Hardeland U
PROVIDER: S-EPMC1920262 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Hardeland Ulrike U Kunz Christophe C Focke Frauke F Szadkowski Marta M Schär Primo P
Nucleic acids research 20070525 11
Human Thymine-DNA Glycosylase (TDG) is a member of the uracil DNA glycosylase (UDG) superfamily. It excises uracil, thymine and a number of chemical base lesions when mispaired with guanine in double-stranded DNA. These activities are not unique to TDG; at least three additional proteins with similar enzymatic properties are present in mammalian cells. The successful co-evolution of these enzymes implies the existence of non-redundant biological functions that must be coordinated. Here, we repor ...[more]