Ontology highlight
ABSTRACT:
SUBMITTER: Muckenfuss H
PROVIDER: S-EPMC1920263 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Muckenfuss Heide H Kaiser Julia K JK Krebil Erika E Battenberg Marion M Schwer Christina C Cichutek Klaus K Münk Carsten C Flory Egbert E
Nucleic acids research 20070521 11
APOBEC3G (A3G), a member of the recently discovered family of human cytidine deaminases, is expressed in peripheral blood lymphocytes and has been shown to be active against HIV-1 and other retroviruses. To gain new insights into the transcriptional regulation of this restriction factor, we cloned and characterized the promoter region of A3G. Transcriptional start sites were identified by 5'-rapid amplification of cDNA ends analysis. Luciferase reporter assays demonstrated that a 1025 bp A3G pro ...[more]