Ontology highlight
ABSTRACT:
SUBMITTER: Hoffmann C
PROVIDER: S-EPMC3877035 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Hoffmann Christoph C Zimmermann Anika A Hinney Anke A Volckmar Anna-Lena AL Jarrett Harry W HW Fromme Tobias T Klingenspor Martin M
PloS one 20131231 12
Uncoupling protein (UCP) 3 is a mitochondrial inner membrane protein implicated in lipid handling and metabolism of reactive oxygen species. Its transcription is mainly regulated by peroxisome proliferator-activated receptors (PPAR), a family of nuclear hormone receptors. Employing bandshift assays, RNA interference and reporter gene assays we examine an intronic region in the UCP3 gene harboring a cis-element essential for expression in brown adipocytes. We demonstrate binding of SP1 and SP3 to ...[more]