Ontology highlight
ABSTRACT:
SUBMITTER: Sathyanarayana P
PROVIDER: S-EPMC1924484 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Sathyanarayana Pradeep P Menon Madhu P MP Bogacheva Olga O Bogachev Oleg O Niss Knut K Kapelle William S WS Houde Estelle E Fang Jing J Wojchowski Don M DM
Blood 20070402 2
Epo's erythropoietic capacity is ascribed largely to its antiapoptotic actions. In part via gene profiling of bone marrow erythroblasts, Epo is now shown to selectively down-modulate the adhesion/migration factors chemokine receptor-4 (Cxcr4) and integrin alpha-4 (Itga4) and to up-modulate growth differentiation factor-3 (Gdf3), oncostatin-M (OncoM), and podocalyxin like-1 (PODXL). For PODXL, Epo dose-dependent expression of this CD34-related sialomucin was discovered in Kit(+)CD71(high) proeryt ...[more]