Ontology highlight
ABSTRACT:
SUBMITTER: Rhodes MM
PROVIDER: S-EPMC2214751 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Rhodes Melissa M MM Kopsombut Prapaporn P Bondurant Maurice C MC Price James O JO Koury Mark J MJ
Blood 20071109 3
Erythroblasts adhere to central macrophages forming erythroblastic islands in hematopoietic tissues, but the function of these islands is not understood. Murine erythroblastic islands were reconstituted in vitro with macrophages and developmentally synchronous proerythroblasts. Erythroblasts cocultured with macrophages proliferated 3-fold greater than erythroblasts cultured alone. Direct contact with the macrophages was necessary for this enhanced erythroblast proliferation, which resulted from ...[more]