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Exon arrays provide accurate assessments of gene expression.


ABSTRACT: We have developed a strategy for estimating gene expression on Affymetrix Exon arrays. The method includes a probe-specific background correction and a probe selection strategy in which a subset of probes with highly correlated intensities across multiple samples are chosen to summarize gene expression. Our results demonstrate that the proposed background model offers improvements over the default Affymetrix background correction and that Exon arrays may provide more accurate measurements of gene expression than traditional 3' arrays.

SUBMITTER: Kapur K 

PROVIDER: S-EPMC1929160 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature

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Exon arrays provide accurate assessments of gene expression.

Kapur Karen K   Xing Yi Y   Ouyang Zhengqing Z   Wong Wing Hung WH  

Genome biology 20070101 5


We have developed a strategy for estimating gene expression on Affymetrix Exon arrays. The method includes a probe-specific background correction and a probe selection strategy in which a subset of probes with highly correlated intensities across multiple samples are chosen to summarize gene expression. Our results demonstrate that the proposed background model offers improvements over the default Affymetrix background correction and that Exon arrays may provide more accurate measurements of gen  ...[more]

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