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Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae.


ABSTRACT: A 269-kilobase conjugative plasmid, pK29, from a Klebsiella pneumoniae strain was sequenced. The plasmid harbors multiple antimicrobial resistance genes, including those encoding CMY-8 AmpC-type and CTX-M-3 extended-spectrum beta-lactamases in the common backbone of IncHI2 plasmids. Mechanisms for dissemination of the resistance genes are highlighted in comparative genomic analyses.

SUBMITTER: Chen YT 

PROVIDER: S-EPMC1932545 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature

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Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae.

Chen Ying-Tsong YT   Lauderdale Tsai-Ling TL   Liao Tsai-Lien TL   Shiau Yih-Ru YR   Shu Hung-Yu HY   Wu Keh-Ming KM   Yan Jing-Jou JJ   Su Ih-Jen IJ   Tsai Shih-Feng SF  

Antimicrobial agents and chemotherapy 20070525 8


A 269-kilobase conjugative plasmid, pK29, from a Klebsiella pneumoniae strain was sequenced. The plasmid harbors multiple antimicrobial resistance genes, including those encoding CMY-8 AmpC-type and CTX-M-3 extended-spectrum beta-lactamases in the common backbone of IncHI2 plasmids. Mechanisms for dissemination of the resistance genes are highlighted in comparative genomic analyses. ...[more]

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