Ontology highlight
ABSTRACT:
SUBMITTER: Boxus M
PROVIDER: S-EPMC1933320 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Boxus Mathieu M Tignon Marylène M Roels Stefan S Toussaint Jean-François JF Walravens Karl K Benoit Marie-Ange MA Coppe Philippe P Letesson Jean-Jacques JJ Letellier Carine C Kerkhofs Pierre P
Journal of virology 20070425 13
Respiratory syncytial viruses (RSV) are one of the most important respiratory pathogens of humans and cattle, and there is currently no safe and effective vaccine prophylaxis. In this study, we designed two codon-optimized plasmids encoding the bovine RSV fusion (F) and nucleocapsid (N) proteins and assessed their immunogenicity in young calves. Two administrations of both plasmids elicited low antibody levels but primed a strong cell-mediated immunity characterized by lymphoproliferative respon ...[more]