Whole genome expression profiling reveals a significant role for immune function in human abdominal aortic aneurysms.
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ABSTRACT:
SUBMITTER: Lenk GM
PROVIDER: S-EPMC1934369 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Publications
Whole genome expression profiling reveals a significant role for immune function in human abdominal aortic aneurysms.
Lenk Guy M GM Tromp Gerard G Weinsheimer Shantel S Gatalica Zoran Z Berguer Ramon R Kuivaniemi Helena H
BMC genomics 20070716
<h4>Background</h4>Abdominal aortic aneurysms are a common disorder with an incompletely understood etiology. We used Illumina and Affymetrix microarray platforms to generate global gene expression profiles for both aneurysmal (AAA) and non-aneurysmal abdominal aorta, and identified genes that were significantly differentially expressed between cases and controls.<h4>Results</h4>Affymetrix and Illumina arrays included 18,057 genes in common; 11,542 (64%) of these genes were considered to be expr ...[more]
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