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Faster rates of post-puberty kidney deterioration in males is correlated with elevated oxidative stress in males vs females at early puberty.

ABSTRACT: BACKGROUND: Post-puberty deterioration of kidneys is more rapid in males than in females. To reveal the underlying molecular mechanisms for this difference, we analyzed gender-dependent gene expression in kidneys of three groups of 36 day-old rats. RESULTS: The number of genes exhibiting gender-dependent expression was highly influenced by the genetic background of the rat group examined. 373, 288 and 79 genes showed differential gene expression between males and females (p = 0.001) in US, Mhm and Mhm*BN rats, respectively. Of all gender dependently expressed genes, only 39 genes were differentially expressed in all tested groups and the direction of expression change was the same for those genes for all groups. The gene expression profile suggests higher metabolic and transport activities, enhanced cell proliferation, elevated oxidative stress, and altered vascular biology in males. Furthermore, elevated levels of superoxide anion (two- to three-fold) in males compared to females were detected at early puberty, but neither at pre-puberty nor at late puberty/early adulthood. CONCLUSION: Our data suggest that early puberty, with gender-related elevation in oxidative stress in males, is a key compromising factor on kidneys in males.

SUBMITTER: Li L

PROVIDER: S-EPMC1934371 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature

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Faster rates of post-puberty kidney deterioration in males is correlated with elevated oxidative stress in males vs females at early puberty.

Li Li L Boehn Susanne N SN Yu Xiaolei X Zhang Qingqin Q Kenzelmann Marc M Techel Dieter D Mohamed Salah A SA Jakob Petra P Kraenzlin Bettina B Hoffmann Sigrid S Gretz Norbert N

BMC genomics 20070709

<h4>Background</h4>Post-puberty deterioration of kidneys is more rapid in males than in females. To reveal the underlying molecular mechanisms for this difference, we analyzed gender-dependent gene expression in kidneys of three groups of 36 day-old rats.<h4>Results</h4>The number of genes exhibiting gender-dependent expression was highly influenced by the genetic background of the rat group examined. 373, 288 and 79 genes showed differential gene expression between males and females (p = 0.001) ...[more]

PMID: 17620128

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Project description:Low-frequency urban noise can interfere with avian communication through masking. Some species are able to shift the frequency of their vocalizations upwards in noisy conditions, which may reduce the effects of masking. However, results from playback studies investigating whether or not such vocal changes improve audibility in noisy conditions are not clear; the responses of free-ranging individuals to shifted signals are potentially confounded by functional trade-offs between masking-related audibility and frequency-dependent signal quality. Black-capped chickadees (Poecile atricapillus) naturally sing their songs at several different frequencies as they pitch-shift to match conspecifics during song-matching contests. They are also known to switch to higher song frequencies in response to experimental noise exposure. Each male produces both high- and low-frequency songs and absolute frequency is not a signal of aggression or dominance, making this an interesting species in which to test whether higher-frequency songs are more audible than lower-frequency songs in noisy conditions. We conducted playback studies across southern and central British Columbia, Canada, using paired song stimuli (high- vs low-frequency songs, n = 24 pairs) embedded in synthetic background noise created to match typical urban sound profiles. Over the course of each playback, the signal-to-noise ratio of the song stimuli was gradually increased by raising the amplitude of the song stimuli while maintaining background noise at a constant amplitude. We evaluated variation in how quickly and aggressively territorial males reacted to each of the paired stimuli. We found that males responded more quickly to playbacks of high- than low-frequency songs when high-frequency songs were presented first, but not when low-frequency songs were first. This difference may be explained by high-frequency songs being more audible combined with a carry-over effect resulting in slower responses to the second stimulus due to habituation. We observed no difference in overall aggression between stimuli. These results suggest that high-frequency songs may be more audible under noisy conditions.

Dataset Information

Faster rates of post-puberty kidney deterioration in males is correlated with elevated oxidative stress in males vs females at early puberty.

Publications

Faster rates of post-puberty kidney deterioration in males is correlated with elevated oxidative stress in males vs females at early puberty.

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